https://www.youtube.com/watch?v=gVuabEckMMA

(From https://www.reddit.com/r/Piracy/comments/kqw0si/guide_on_how_to_easly_run_pirated_games_on_linux/?rdt=44586)

• Download pirated game
• Install Lutris and find your game in it
• Install original game through Lutris
• Using WINEPREFIX=“/Lutris/game/prefix (eg. /home/USER/Games/originalgame)” wine piratedgame.exe install pirated game into this Lutris prefix
• Apply crack
• (optional) Copy your saves into this prefix’ c:\Users\Documents folder
• Change game executable in lutris from platform exe (like EGS or Steam) to your pirated game’s .exe
• Run game using Lutris.

If Lutris is having issues, you may have better luck using Bottles, also trying the non flatpak version if you are currently using flatpak.

I think the only reasonable way to do that would be using AI since the sponsors are placed randomly throughout usually. Unless you listen to a specific podcast and they do same length of sponsor in same time slot every video you could automate something that cuts it out.